Reagan Memorial Baptist Girls’ Secondary School was founded in 1941 by the Southern Missionary Board, USA. It is located at 29 Commercial Avenue, Yaba, Lagos, Nigeria.

Reagan Memorial Baptist Girls’ School started as a primary school in 1948. Three years later, the Secondary school was founded at the present location.

The school was named in honor of Ms. Lucille Reagan, a missionary who wanted the idea of having a separate Baptist high school for girls. Ms. Reagan passed away of yellow fever in 1936. Ms. Cora Ney Hardy was the first principal. The first African principal was Ms. Adeola Adegbite.

As a Christian institution, the focus was to develop girls as high intellectuals, good-spirited, morally-sound and highly-cultured in the society. Girls were divided into 4 houses: Lumbley(yellow), Agbebi (Blue), Sanders (Red), Reagan (Green).

They competed for laurels at  Annual Inter House Athletics Competitions. Extra curricular activities included Girls' Auxiliary (GA), Lydia, Drama, Gardening, Literary and Debating Society, Red Cross. Thrift and Choral Clubs.